Ottawa researcher says virus-based treatment blows up leukemia cells ‘like popcorn’ (video)

Within a day of an injection, the membranes of the cancer cells are compromised. The cell membranes deteriorate and the cells blow up “like popcorn,” says hematologist Dr. David Conrad, the senior co-author of the study. Three doses cured 60 per cent of the mice, and 80 per cent of the experimental population had long-term survival. This is a “paradigm shift” in the understanding of using virus-based therapies to treat acute leukemia, the researchers said in Blood Cancer Journal, which is associated with the prestigious science journal Nature. The news generated a lot of buzz at a recent international cancer conference in Quebec City, says Conrad, who’s part of a research team with members from the Ottawa Hospital Research Institute, the Ottawa Hospital and the University of Ottawa. “When the immune system sees these cells, it gets rid of the debris. It forms an immune response. If new cancer cells grow, the immune system recognizes them and kills them,” says Conrad. “There’s a lot of interest because it’s not just potent, it’s safe.” For about a decade, Ottawa Hospital Research Institute scientists including Dr. John Bell, who was the other senior researcher in this study, have been investigating viruses as cancer therapeutics. But there’s an added wrinkle to using viruses to attack leukemia. Blood is a liquid, not a solid, as with most cancer tumours.


Clearwater, FL Gum Disease Treatment is Now Performed Using Laser Gum Surgery at Northwood Dental

Even worse, research indicates that untreated gum disease can cause or aggravate illness elsewhere in the body. Unfortunately, many people resist gum disease treatment because until now, traditional options of treatment involved a scalpel. Scalpel surgery may cause greater discomfort, because it entails cutting into the gum line to dig away the bacteria that causes periodontal disease. Northwood Dental is one of only a handful of dental professionals to offer the minimally-invasive LANAP gum disease treatment. LANAP is the only FDA-cleared laser gum surgery to restore health to teeth and gums with remarkable precision and minimal pain. Northwood Dental uses the PerioLase MVP-7, a unique, FDA-cleared dental laser that has revolutionized gum disease treatment, because it removes bacteria from gum pockets without compromising nearby healthy tissue. While the scalpel can destroy some of the healthy gum tissue, the laser identifies and kills only bacteria and diseased tissue. The undamaged healthy tissue can begin to reattach to the tooth root surfaces. Backed by scientific and microscopic tissue studies, laser gum surgery can even reverse bone loss by generating new bone growth around existing teeth. Bone regeneration is a new discovery unique to this gum disease treatment. Healthy teeth and gums are essential to good health. Northwood Dental hopes more patients will take the opportunity to learn about laser gum surgery by calling or visit their website. About Northwood Dental Northwood Dental is a general practice offering personalized dental care for patients in Clearwater, FL since 2003. Drs. Jill Hagan and David Wagner both bring advanced dental technology to the practice. Dr.

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New Treatment may Help Prevent 80 Percent Neural Defects in Newborns

What is an even better is that this new procedure was able to treat certain NTDs that are not currently responsive to Folic Acid. Nicholas Greene, Professor of Developmental Neurobiology at the ICH, said, We are still in the early stages of this research, but we hope that these promising results in mice can eventually be replicated with human NTDs. If it is found to be effective, this nucleotide treatment could boost the effects of folic acid and offer expectant mothers an even more reliable safeguard against relatively common defects like spina bifida. ICH is the research partner of Great Ormond Street Hospital for Children NHS Foundation Trust. The team hopes that the same treatment can help prevent a number of NTDs in humans too. Globally spina bifida and anencephaly are among the few NTDs that still effect 1 in 1000 pregnancies with some countries showing higher percentage than others. Folic Acid recommended for pregnant women in the early stages of their pregnancy helps prevent 20-80 percent of these birth defects in children, at a time when their central nervous system is developing inside the womb. Folic acid works by helping the embryos neural tube to close normally, which is an essential step of development. However, a number of NTDs are still unresponsive to Folic Acid and the new treatment might help bridge this gap. Experts believe that one reason why folic acid might not be affective is when a genetic blockage stops folic acid from reaching the embryo. The new treatment plans to add nucleotides, which are needed to make DNA as cells divide in the growing embryo. These nucleotides can bypass the blockage in the way folic acid is handled, and ensure the growth of crucial cells in the embryo. The team also believes that because NTDs may be due to a number of different causes, the treatment route also has to be different with varying combinations. In a previous study the vitamin inositol was found to have a protective effect and researchers are also testing its viability in reducing NTDs.

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