Novel Designed Molecules Could Stop Colon Cancer Metastasis

and president of the Ikerbasque Executive Committee. “As well as being relevant for the control of cancer and metastasis, this work shows that in the Basque Country there are teams of researchers in academic institutions and in companies with the necessary experience and collaboration capacity to address multidisciplinary projects of biomedical relevance, by combining synthetic and computational chemistry with the structural analysis of the mechanism of action and the biological validation of the generated molecules”, states Dr. Francisco Blanco, Ikerbasque Research Professor at CIC bioGUNE. Impact of cancer and metastasis Cancer is the second highest cause of human mortality and its incidence increases with age. Thanks to the progress in early detection and the control of detected tumours, the survival rate has been steadily increased and, in this sense, it is expected that further progress in these two aspects of the disease will be achieved. Nowadays, 90% of deaths from cancer are caused by the reappearance of the original tumour in a different part of the body, a process known as metastasis. This process takes place when a cancer cell from the original tumour migrates to another organ in the patient’s body, generating a new tumour. Colon cancer, is not among the highest mortality rate cancers, but it often develops metastasis in the liver, which it is. In fact this is the organ where most frequently the metastasis from tumours in other parts of the body appear. This happens because the liver works as a blood and lymph filter and, therefore, cancer cells in these fluids may be trapped in it. The lethal danger of cancer cells moving around the body is what pushes the researchers to find therapies to stop metastasis. More information: Sebastian, E.

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Dr. Oz’s Colonoscopy Finds Pre-cancerous Polyp: What Can He Teach Us?

Dr. Mehmet Oz and Dr. Jonathan Lapook.

Mehmet Oz just might be the last person on earth people would expect to get a colon polyp. He’s physically fit (he left me in the dust the last time we ran together), he eats a healthy diet, he doesn’t smoke, and he has no family history of colorectal cancer or colon polyps. But several weeks ago, when Mehmet had his first screening colonoscopy at age 50, I removed a small adenomatous polyp that had the potential to turn into cancer over time. Statistically, most small polyps like his don’t become cancer. But almost all colon cancers begin as benign polyps that gradually become malignant over about 10-15 years. Since there’s no way of knowing which polyps will turn bad, we take them all out. The good news is there’s plenty of opportunity to prevent cancer by removing these polyps while they are still benign. But only about 63 percent of Americans between ages 50 and 75 get screened for colorectal cancer. Patients who smoke, eat diets high in red and processed meats, drink too much alcohol, don’t exercise, and are obese are at increased risk of colorectal cancer. So Mehmet’s healthy lifestyle may actually have protected him from having a bigger polyp – or even colorectal cancer by now. But the bottom line is this: no matter what you do, you can’t totally eliminate your risk of developing this disease, which is expected to strike 143,000 Americans and kill over 51,000 in 2010. About the same number of women is affected as men. And about 70 percent of patients have no family history of colorectal cancer.

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Reduce risk from cancer-causing polyps

EXCLUSIVE: Marcheline Bertrand, French actress and mother of Angelina Jolie, has died of cancer

A fiber-rich diet with plenty of vegetables, fruits, whole grains and beans is commonly associated with a lower risk of colon cancer. Yet in one recent large population study, fiber consumption was unconnected to colon cancer occurrence. No randomized clinical trial the most convincing type of human study has shown that increasing peoples dietary fiber decreases the first appearance or recurrence of polyps either. The problem with the randomized clinical trials so far may be their short duration. None has been more than four years long. It is probable that diets affect on colon cancer takes place over a longer period of time. Despite the lack of supporting evidence from randomized clinical trials, you should still eat the lowfat, mostly plant-based diet researchers recommend to lower colon cancer risk. This eating style might inhibit colon cancer in several ways, such as decreasing polyp formation, slowing the growth of polyps, or blocking their transition from benign to cancerous. Other steps you could take to decrease the formation of colon polyps include limiting your red meat consumption and meeting the current recommendations for folate. This nutrient is found in dark green leafy vegetables, orange juice and other plant foods, and its often low in Americans diets. You should also get enough calcium and vitamin D.

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Colon Cancer Screening Should Start At 50, Says American College Of Physicians

Colon Cancer Screenings Work, Twin Studies Report

Colonoscopy, sigmoidoscopy and even fecal blood

According to the ACP, most adults should get screened for colon cancer beginning at age 50. People with a family history of colon cancer and others considered high-risk should get screened starting at age 40, or 10 years younger than the age of when your youngest family member was diagnosed with colon cancer. Other risk factors for colon cancer include age, race – African Americans have highest rates in U.S. – history of polyps or inflammatory bowel disease. A colonoscopy is considered the “gold standard” of screening tools, according to the College. During the 30-minute procedure, a thin, flexible tube with a tiny camera is guided through the large intestine to look for precancerous growths called polyps so they can be removed before they turn into cancer. The new guidance recommends people should get a colonoscopy once every 10 years. For those who want other options, there is a stool blood test the College recommends people get annually, or a flexible sigmoidoscopy – a thin camera tube that’s inserted that looks at the lower parts of the colon – that people should get every five years. “We encourage patients to engage in shared decision making with their physician when selecting a colorectal cancer screening test so that they understand the benefits and harms,” Hood said in the statement . “The success of any screening program, especially colorectal cancer screening, is dependent on the appropriate testing and follow-up of patients with abnormal screening results as well as following up with patients for repeat testing at designated intervals.” The College does not recommend continued screening for adults over 75 because the harms – such as the need for biopsies if something is found – would outweigh the benefits at that age because the cancers may be too slow-growing to ever cause a problem. The College’s position statement is available online in the March 6 issue of Annals of Internal Medicine . Colon cancer is expected to take more than 51,000 American lives this year, second to only lung cancer. A recent study says the procedure actually saves lives. It found people who got a colonoscopy were 53 less likely to die from colon cancer than people who weren’t screened, HealthPop reported. “There’s no question that these are findings that we can take to the bank,” Robert Smith, director of screening at the American Cancer Society, said at the time.

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colonoscopy, colon cancer, colorectal screening guidelines

Two other recommended screening methods, however, also greatly reduce colon cancer mortality, the researchers found. Flexible sigmoidoscopy provides a 40 percent lower risk of dying from colon cancer, while annual fecal blood testing offers a 32 percent reduced death risk. “The inclusion of all these tests in the guidelines of major organizations continues to make sense,” said Dr. Durado Brooks, director of prostate and colorectal cancers for the American Cancer Society. “Quite honestly, many patients don’t have access to colonoscopy or are not willing to undergo a screening colonoscopy. Many studies have shown that offering patients options will increase the likelihood that they will complete some form of screening, and that is what is most important.” The results come from a pair of studies testing the long-term health benefits of screening for colon cancer. The first study investigated the use of colonoscopy and flexible sigmoidoscopy among a group of almost 89,000 health professionals during a 20-year period. Colonoscopy uses a thin tube equipped with a camera to examine the entire length of the colon in a procedure for which patients are usually sedated. Flexible sigmoidoscopy is a similar procedure but with a shorter tube that examines less of the colon, so patients do not have to be sedated. The study found colonoscopy was more effective in preventing cancer throughout the entire colon, but that both procedures greatly reduced the overall risk of colon cancer death, said Dr. Andrew Chan, an assistant professor at the Massachusetts General Hospital Gastrointestinal Unit and the co-senior author of the report. “Colonoscopy was superior to flexible sigmoidoscopy in terms of reducing the risk of colon cancer throughout the colon,” Chan said. “But this study really does support the existing guidelines and recommendations for individuals to undergo screening with either colonoscopy or sigmoidoscopy.

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Colon Cancer Screening Tied To Better Outcomes

Seaman NEW YORK | Fri Jun 21, 2013 3:56pm EDT NEW YORK (Reuters Health) – People who are diagnosed with colon cancer after routine colonoscopies tend to have better outcomes and less advanced cancers than people diagnosed based on symptoms, says a new study. Those who were diagnosed with colon cancer as a result of symptoms were three times more likely to die during the study than the patients diagnosed after colonoscopy screenings, researchers found. “It’s in line with its current use. It shows that colonoscopy appears to be beneficial in reducing deaths in those diagnosed with colorectal cancer,” said Dr. Chyke Doubeni, who studies colonoscopy use but wasn’t involved in the new research. Colon cancer is the third most common cancer and the second leading cause of cancer death in the U.S., according to the government-backed U.S. Preventive Services Task Force (USPSTF), which recommends that people between ages 50 and 75 get screened by colonoscopy every ten years. During a colonoscopy, a doctor uses a long flexible tube equipped with a tiny video camera to see the interior of the colon. According to the study authors, the incidence of colon cancer in the U.S. has dropped by about 6 percent since the first national colonoscopy guidelines were introduced in 2000 – mostly due to doctors catching and removing precancerous polyps during screening. Still, the U.S. Centers for Disease Control and Prevention reports that about 22 million people are not up-to-date with their colon cancer screenings. For the new study, Dr.

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Grape Seed Extract Provides A Natural Treatment Option For Colorectal Cancer

They found that similar concentrations of GSE exerted a more profound effect in eradicating more advanced stages of colon cancer, indicating that the natural compound may provide an effective treatment option for more advanced forms of the disease. Ms. Derry noted “It required less than half the concentration of GSE to suppress cell growth and kill 50 percent of stage IV cells than it did to achieve similar results in the stage II cells.” The study team discovered that GSE targets colorectal cancer through inducing oxidative stress that leads to the programmed cell death known as apoptosis. Ms. Derry concluded “The many bioactive compounds of GSE are able to target multiple mutations. The more mutations a cancer presents, the more effective GSE is in targeting them.” Nutrition experts recommend supplementing with a standardized whole grape seed extract (150 to 250 mg) daily to provide a protective shield against colon and digestive cancers. Sources for this article include: About the author: John Phillip is a Certified Nutritional Consultant and Health Researcher and Author who writes regularly on the cutting edge use of diet, lifestyle modifications and targeted supplementation to enhance and improve the quality and length of life. John is the author of ‘Your Healthy Weight Loss Plan’, a comprehensive EBook explaining how to use Diet, Exercise, Mind and Targeted Supplementation to achieve your weight loss goal. Visit My Optimal Health Resource to continue reading the latest health news updates, and to download your copy of ‘Your Healthy Weight Loss Plan’. Stay informed! FREE subscription to the Health Ranger’s email newsletter Get breaking news alerts on GMOs, fluoride, superfoods, natural cures and more… Join over four million monthly readers. Email privacy 100% protected.

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Phase III Colon Cancer Prevention Therapy Trial Now Open for Enrollment

In an earlier trial, people who had had adenomas removed from their colon who then took daily eflornithine and sulindac for three years lowered their risk of developing another adenoma during the following three years to less than one third of what it was for those who did not take the drugs. And they lowered their chances of developing a high-risk adenoma during that time by 90 percent. The PACES trial is being conducted under CPP’s IND, supported by the NCI, and primarily managed by SWOG. “This is a huge milestone for all of us today,” said Jeffrey Jacob, CEO of Cancer Prevention Pharmaceuticals. “We have worked collaboratively with the NCI, SWOG, and the US Food and Drug Administration (FDA) for over three years to get this pioneering trial up and running.” CPP has agreements in place with both SWOG and the NCI providing CPP exclusive access to the data from this trial for commercial and regulatory purposes. The Company is also considering supplementing this trial with a parallel study in Europe or Asia. Jacob said, “CPP was created to pave a regulatory pathway so that others in the industry would consider cancer risk-reduction therapythe prevention of cancer before it occursas a viable product development model that the Company believes holds the key to reducing death rates from cancer.” About Colon Adenoma Therapy (CAT) Polyps begin in the cells of glandular structures lining the colon. Most polyps are benign, but one kind is the cause of greater concernthe Colon Adenomatous Polyp (adenoma). This growth is associated with DNA changes in the lining of the colon. Up to 10% of these polyps can become cancerous within a 10 year period if undetected or ignored. For individuals with multiple polyps, the chance of at least one of these polyps becoming cancerous is very high. However, if malignant polyps are detected early, 90% of patients survive at least five years. Some individuals have a genetic tendency to develop polyps. Individuals age 50 or older have a higher risk of developing Colon Adenomatous Polyps. In addition to genetic factors, these polyps are associated with a diet high in fat and beef and low in fiber.


To Prevent Colon Cancer, Get Your Butt to the Doctor

ht couric mi 130306 wblog To Prevent Colon Cancer, Get Your Butt to the Doctor

And iffriends orloved ones resist the idea, Couric said to tell them to do it for the people who love and depend on them. Also, if your partner doesnt want to get screened, join them and suggest his and hers colonoscopies! she tweeted. Katie Couric Tweeted, “Get Your Butt to the Doctor!” Credit: Katie Couric. 3. Dont Die of Embarrassment There may be blood in stool, a change in bowel habits, diarrhea or a change in weight, experts from the NIH noted. Experts from Dana Farber added, A month or more narrowing of the stools, straining, change in stool shape are all symptoms of bowel problems. As many of our tweeters noted, people often ignore these symptoms or are too embarrassed to talk to the doctor about them. Here again, our chatters said to get over it. Get your butt to the doctor, Couric tweeted this comment was retweeted more than a dozen times. As Besser pointed out, however, other than polyps there may be no other symptoms in the early stages of the disease. Thats why its so important to have regular check-ups and get screened on a schedule set by you and your doctor. 4. Know the Risks Age is an important risk factor. Colon and rectal cancers most often strike people over the age of 50, but the disease can strike at any age. Although anyone can get colorectal cancer, its deadliest for minorities, because theyre less likely to get tested or seek treatment, the experts from the Colon Cancer Alliance said.

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The Six Early Warning Signs And Symptoms Of Colon Cancer

A healthy lifestyle may prevent that visit to the doctor’s office. The Mayo Clinic lists six early warning signs and symptoms that a person may have colon cancer. Colon cancer signs include: blood in the stool cramps, gas, abdominal pain or other colon problems that persist over a period of time diarrhea or constipation, if this is a change in regular bowel habits and lasts for more than a few weeks a feeling of fatigue or weakness feeling as if the bowel has not emptied all the way after a bowel movement rapid, unexplained weight loss Some people experience no symptoms at all and are completely surprised to learn they have colon cancer. Cancer research indicates that colon cancer occurs when healthy colon cells get altered and grow out of control. Cancer cells begin to form in the lining of the intestines, but may take years to develop into a detectable colon cancer tumor. Precancerous polyps that are either flat or look like mushrooms form sores, called lesions, along the sides of the large intestines. Who is at Risk for Colon Cancer? These are the primary risk factors for colon cancer: being over 50 years old being African American having a family history of colon cancer a low fiber, high fat diet a diet high in red meat and processed lunch meat a lack of regular exercise having diabetes smoking When to See a Doctor for Colon Cancer Symptoms Anyone with concerns about symptom should set an appointment with a doctor, who will order a series of tests. These include blood tests to determine the possible cause of the symptoms, but this will not detect colon cancer. A doctor will also perform a colonoscopy, an uncomfortable procedure where a small camera attached to a tube is used to video monitor the entire colon, and if anything unusual is noticed, tissue samples will be biopsied. A barium contrast-dye enema will then be administered so the colon shows up on X-rays better. It is likely that the doctor will also order a CT scan to get a detailed picture of the inside of the colon. If colon cancer is diagnosed, surgery will be scheduled to remove pieces of the large intestines. The doctor may also recommend a course of radiation and chemotherapy. What About Colon Cancer Treatment Alternatives? While the Mayo Clinic and other allopathic treatment centers state no known cure for any kind of cancer, there is a second path to consider: cancer prevention by way of a healthier lifestyle.

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Patient Comments: Colon Cancer – Symptoms

It was difficult to eat because I felt full most of the time. Swelling of the lower abdomen was also a symptom which appeared at times. My bowel motions swung between chronic constipation and diarrhea. Low energy and anemia were big signs for me. I spent a lot of time in bed not knowing why and hiding it from my family. My skin in face was yellow due to spread to liver. Diagnosis happened through colonoscopy. I am under 65 and this is a 65+ year old type of cancer and so I was misdiagnosed for at least a year. Was this comment helpful? Was this comment helpful? Yes

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Colorectal Cancer Increasing In Young Adults

Colorectal Polyps and Cancer

The death toll from this cancer is 50,000 every year. Although scientists aren’t sure why this cancer is attacking more of the younger generation they do have a few suspicions. Study says colorectal cancer increasing in young adults by 2 percent each year in certain groups. Figures Among the Young Adults Even though colorectal cancer over-all has been on the decline, they attribute this fact to more widespread screening. If they can find the cancer early enough, they can treat it successfully. For white men ages 20 to 49, there were 8.4 cases out of 100,000 people diagnosed with colorectal cancer during the years of 1992 to 1995. They did the study again in the years 2002 to 2005 and found that the rate had risen to 10.2. This is a 21 percent increase in a ten-year period. They conducted the same study on women ages 20 to 49. In the years 1992 to 1995, the rate was 6.9. They did the study again in the years of 2002 to 2005 and those numbers had risen to 8.8, which mean a 28 percent increase. They did the same sturdy with Latinos. The increase was 33 percent for men, but not statistically significant for women. There was no increase for African-Americans, but unfortunately, this group of 20 to 49-year-old men and women has a higher risk.

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Previous studies have made the connection between obesity and colon cancer, a link recognized by the US National Cancer Institute. But the current study, which appeared in the American Journal of Gastroenterology, is the first to point to a higher risk of colon polyps – also known as adenomas – in heavy people. “Because there is a known association between obesity and cancer, there is a logical extension to expect a connection between obesity and the step before cancer, which is adenoma,”said Hutan Ashrafian from Imperial College, London, who co-authored the study. Ashrafian and his colleagues analyzed data from 23 studies involving more than 100,000 people across the United States, Asia and Europe, looking at the relationship between polyps and body mass index, or BMI, a measure of weight relative to height. All the studies followed World Health Organization (WHO) guidelines that define people with a BMI over 25 as overweight and above 30 as obese. In most studies, polyps were identified during colonoscopy procedures while two large studies used self-reported questionnaires. Overall, researchers found that 22 per cent of overweight and obese people had colon polyps, compared to 19 per cent in people of normal weight. The polyp risk grew with increasing BMI. “The findings suggest that obesity may be having an effect (on cancer development) much earlier than we thought,” said Ashrafian, who with his fellow authors recommended timely colon cancer screening for overweight and obese people. The findings couldn’t say whether obesity causes polyps by itself, but if it does, that may be bad news for a world where obesity is on the rise. According to the World Health Organization, about 500 million people worldwide are obese. Colon cancer killed more than half a million people worldwide in 2008, WHO figures show.

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Heavy people more likely to have colon polyps: Study

Promotion tile: Weight Loss Guide

How Does Colorectal Cancer Develop? Colorectal cancer usually begins as a “polyp,” a nonspecific term to describe a growth on the inner surface of the colon. Polyps are often non-cancerous growths but some can develop into cancer. The two most common types of polyps found in the colon and rectum include: Hyperplastic and inflammatory polyps. Usually these polyps do not carry a risk of developing into cancer. However, large hyperplastic polyps, especially on the right side of the colon, are of concern and should be completely removed. Adenomas or adenomatous polyps. Polyps, which, if left alone, could turn into colon cancer. These are considered pre-cancerous. Although most colorectal polyps do not become cancer, virtually all colon and rectal cancers start from these growths. People may inherit diseases in which the risk of colon polyps and cancer is very high. Colorectal cancer may also develop from areas of abnormal cells in the lining of the colon or rectum.

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